Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature

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Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature.

The ability to distinguish mechanical from thermal input is a critical component of peripheral somatosensory function. Polymodal C fibers respond to both stimuli. However, mechanosensitive, modality-specific fast-conducting tactile and nociceptor afferents theoretically carry information only about mechanical forces independent of the thermal environment. We hypothesize that the thermal environ...

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Introduction: Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. Methods: In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into...

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Nociceptive primary afferents have three surprising properties: they are highly complex in their expression of neurotransmitters and receptors and most probably participate in autocrine and paracrine interactions; they are capable of exerting tonic and activity-dependent inhibitory control over incoming nociceptive input; they can generate signals in the form of dorsal root reflexes that are tr...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2016

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00796.2015